منابع مشابه
Adjuvant analgesics in neuropathic pain.
Conventional analgesics have limited efficacy in the management of neuropathic pain. An adjuvant analgesic is a drug that has a primary nonpain indication but which may be analgesic in certain circumstances, and many of these have established a role in the pharmacological treatment of neuropathic pain. The number needed to treat is an indirect statistical measure that can be used to compare rel...
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The advantages of the benzodiazpines as oral premedicants are: clear anxiolytic and sedative effect; less clear amnesic action which may prevent the recall of the time spent lying on an uncomfortable theatre trolley, but not necessarily recall of the journey to the operating theatre, or induction of anaesthesia; convenient route of administration; long duration of action of 5-8 h which simplifi...
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The ideal sedative or analgesic agent should have a rapid onset of activity, a rapid recovery after drug discontinuation, a predictable dose response, a lack of drug accumulation,and no toxicity. Unfortunately, none of the earlier analgesics, the benzodiazepines,or propofol share all of these characteristics. Patients who are critically ill experience numerous physiologic derangements and commo...
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Tricyclic and certain other antidepressants are widely used to treat chronic and neuropathic pain states. The first report of such activity appeared 40 years ago, soon after the introduction of tricyclic antidepressants into clinical medicine. Their efficacy in this regard is now well established through both clinical trials, as well as systematic and meta-analysis approaches. Although the mech...
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Pain is both a symptom and a sensation. As a symptom, pain signals danger and thus provokes appropriate reflexes. Sher rington,2 accordingly, described pain as “the psychical adjunct of an imperative protective reflex.” From a therapeutic viewpoint, pain is a valuable clinical symptom to the practitioner. It also follows that the management of pain— a symptom— must be subject to the same limit...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 1994
ISSN: 0885-3924
DOI: 10.1016/0885-3924(94)90112-0